Health Committee Projects
OFA DNA Repository
PBGVs that participate in the National DNA collection must complete the CHIC DNA Repository Form and Health survey. Please review and have all information available at the time of the DNA collection.
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The following request has been sent from Peter Marks, Health Officer in the Basset Griffon Vendeen Club in the UK. Please make initial contact with Peter Marks, PMarks1262@aol.com, to briefly discuss your PBGV's condition. This will insure that your PBGV's DNA will be beneficial to the epilepsy research being conducted at Animal Health Trust in the UK. Thank you for your cooperation and participation.
Research into Idiopathic Epilepsy in the Petit and Grand Basset Griffon Vendeen in the UK.
Over the past 15 years the BGV Club of the UK has been collecting DNA samples from both Petit and Grand Basset breeds in an attempt to find the genetic cause of Idiopathic Epilepsy in our breeds. This is the form of epilepsy that is caused by a genetic mutation and not by physical or environmental factors. The Club works in collaboration with the Animal Health Trust (AHT), a charitable foundation largely financed by our Kennel Club but also by other breed clubs and donors. The research into Idiopathic Epilepsy is led by Dr Cathryn Mellersh an internationally renowned geneticist who is also working on the genetic causes of Primary Open Angle Glaucoma (POAG) in the PBGV.
Several international sequencing trials in recent years both in the US and Finland have failed to find the mutation causing Idiopathic Epilepsy in our breeds and after analysing the results it was determined that the quality of the base data was insufficiently rigorous to produce a result.
In 2010 the Animal Health Trust requested that all DNA samples submitted from cases of Epilepsy should be accompanied by the results of a group of non invasive further tests to try and eliminate physical and environmental causes of epilepsy and asked the owners to fill in a questionnaire regarding the history of the type and frequency of the seizures. Our Club agreed to pay the costs of these further tests to improve the quality of the data supplied for research and we now hold full data sets for some 30 cases under the new protocol from the UK, Holland, Germany and Australia including 3 from the USA. The Animal Health Trust has advised that they need a minimum of 48 confirmed cases before they can undertake a preliminary DNA sequencing trial and we are currently raising funds in anticipation of reaching this number of cases. Contributions have been kindly made by breed clubs in Holland, Germany and the USA for which we are most grateful. The French Club has joined the program this year.
We collect the DNA in the form of cheek swabs which are stable and simple for an owner to collect, the further tests to be carried out by a veterinarian comprise full haematology and biochemistry from a blood sample, a bile acid stimulation test, and a neurological examination. In addition the owner is requested to fill in the AHT owners questionnaire and submit the whole directly to the AHT. The swab kits and questionnaires are available from Mrs Helen Ingher in the USA.
Those of you that have had a case of epilepsy in your dogs know only too well what a terrible affliction this can be for both owner and patient so we are appealing to all owners of affected dogs to assist us in this programme. The sooner we can reach the required number of confirmed cases the sooner we can hope to identify the causal mechanism and eliminate the condition from our breeding stock for the benefit of the breed world wide. All information provided is held in strict confidence between the relevant Health Officers and the Animal Health Trust.
Thanking you in advance for your kind cooperation.
Peter Marks, Health Officer, BGV Club UK, PMarks1262@aol.com
Danish Epilepsy in the Petit Basset Griffon Vendeen: Prevalence, Semiology, and Clinical Phenotype by C.H. Gulløv, N. Toft, M.M.N. Baadsager, and M. Berendt. September 2011 Click Here
Comprehensive Breed Health Survey Long-Form (INACTIVE)
- PBGV 2011 Short Form Survey Results 11/2012
- PBGV-Comprehensive Breed Health Survey Results (updated 3/2010)
- PBGV-Comprehensive Breed Health Survey Results (updated 3/2009)
- PBGV-Comprehensive Breed Health Survey Results (updated 3/28/08)